According to Microsoft, runtime error 216, shown below, occurs when windows tries to open an application and the operating system cannot load the program. The problem is caused by infection with the SubSeven Trojan virus. Runtime error 216 can cause permanent damage to your operating system if left unrepaired.

First, let’s look at what a Trojan is and how it works. A Trojan allows intruders to access your computer without you being aware that they are doing that. Once they are using a backdoor to your system, they can steal information, use your computer to send spam, etc.
Microsoft recommends using a good anti-virus program to clear the infection. Using an anti-virus program is a good way to trouble shoot the problem.
Symptoms of Runtime Error 216
This Trojan invades the registry and modifies command files, sometimes with unpredictable results. Some of the common symptoms include:
- Inability to open some programs such as internet explorer
- Random CD/DVD drives opening and closing
- Pop up dialogue boxes appearing randomly
- Appearance and disappearance of important files
- Extremely slow downloads
Repair Procedure
Follow these steps to eliminate the SubSeven Trojan infection:
- Boot to safe mode by pressing the F8 key at start up
- Once the system has booted run a good anti virus program to eliminate the Trojan
However, even people who have a good anti-virus program are still experiencing this problem so that even after the infection has been eliminated, the error message still keeps appearing.
What’s Going on Here?
Runtime error 216 is actually a registry error rather than a system error because it primary mischief is done to the registry so that windows gets confused and tries to execute files that don’t exist or legitimate files that the Trojan has changed their name.
You will need to also use a good registry cleaner to fix all of the entries that the Trojan modified. Once all that is done, the error should disappear for good.
Summary
Any time you have a virus, Trojan or other form of malware that causes a noticeable error in system behavior or performance, you should run a manual anti-virus and spy ware scan. Once that is complete, you should run a good registry cleaner to remove all of the damage and left over junk entries these programs can leave behind after they are dead.
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